Dissection of purified LINE-1 reveals distinct nuclear and cytoplasmic intermediates
نویسندگان
چکیده
The Rockefeller University, Laboratory of Mass Spectrometry and Gaseous Ion Chemistry (New York, NY, United States); Massachusetts General Hospital, Department of Pathology (Boston, MA, United States); Moscow Institute of Physics and Technology, (Dolgoprudny, Russian Federation); Institute for Systems Genetics, New York University School of Medicine, Department of Biochemistry and Molecular Pharmacology (New York, NY, United States); The Rockefeller University, Laboratory of Cellular and Structural Biology (New York, NY, United States); Johns Hopkins University School of Medicine, McKusickNathans Institute of Genetic Medicine (Baltimore, MD, United States); Johns Hopkins University School of Medicine, Department of Pathology (Baltimore, MD, United States); Novosibirsk State University, (Novosibirsk, Russian Federation).
منابع مشابه
Purification of the vertebrate nuclear pore complex by biochemical criteria.
The nuclear pore is a large and complex biological machine, mediating all signal-directed transport between the nucleus and the cytoplasm. The vertebrate pore has a mass of approximately 120 million daltons or 30 times the size of a ribosome. The large size of the pore, coupled to its tight integration in the nuclear lamina, has hampered the isolation of pore complexes from vertebrate sources. ...
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